Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a
نویسندگان
چکیده
منابع مشابه
IgE-mediated anaphylactic degranulation of isolated human skin mast cells.
Isolated human skin mast cells (HSMC) were prepared and cultured overnight before functional and electron microscopic studies. Mast cell suspensions were examined after stimulation with anti-IgE to produce anaphylactic degranulation or examined in buffer-incubated controls. Histamine release was measured in replicate samples. Control, isolated HSMC studied by electron microscopy were well prese...
متن کاملRegulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.
Allergic symptoms result from the release of granular and lipidic mediators and of cytokines by inflammatory cells. The whole process is initiated by the aggregation of mast cell and basophil high-affinity IgE receptors (Fc epsilon RI) by IgE and antigen. We report here that IgE-induced release of mediator and cytokine can be inhibited by cross-linking Fc epsilon RI to low-affinity IgG receptor...
متن کاملProlonged topical application of tacrolimus inhibits immediate hypersensitivity reactions by reducing degranulation of mast cells.
We studied the effects of prolonged topical application of tacrolimus on immediate hypersensitivity reactions. Tacrolimus, betamethasone or petrolatum was applied to the footpad of mice for up to 28 days after immunization, and the foot-swelling response to allergen was estimated. The reactions in tacrolimus-treated mice decreased significantly from day 14, while those in betamethasone-treated ...
متن کاملAbrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a.
BACKGROUND Initiated and regulated by mast cells, allergic responses are balanced through an intricate network of positive and negative signals. We have recently shown that the inhibitory receptor CD300a is expressed on human mast cells and modulates a large array of their functions. OBJECTIVE We sought to evaluate CD300a as a negative regulator of allergic inflammation in vivo by means of a ...
متن کاملEnvironmental Estrogens Induce Mast Cell Degranulation and Enhance IgE-Mediated Release of Allergic Mediators
BACKGROUND Prevalence and morbidity of allergic diseases have increased over the last decades. Based on the recently recognized differences in asthma prevalence between the sexes, we have examined the effect of endogenous estrogens on a key element of the allergic response. Some lipophilic pollutants have estrogen-like activities and are termed environmental estrogens. These pollutants tend to ...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2019.03.005